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KMID : 1130320080510111185
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Korean Journal of Pediatrics
2008 Volume.51 No. 11 p.1185 ~ p.1190
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The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old
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Lee Soo-Young
Kwak Ga-Young
Mok Hye-Rin
Kim Jong-Hyun
Hur Jae-Kyun
Lee Kyung-Yil
Park Joon-Soo
Ma Sang-Hyuk
Kim Hwang-Min
Kang Jin-Han
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Abstract
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Purpose: This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea.
Methods: Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2 0 0 6 to April 2 0 0 7 . Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity.
Results: 1 8 3 preadolescents were enrolled and mean age was 1 1 .4 0 ±0 .5 1 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers ≥0 .1 IU/mL) after Td booster vaccination. Among 1 8 3 vaccinees, 7 3 .8% showed local adverse reactions and 3 7 .2% systemic adverse reactions. Pain at injection site (6 6 .1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (1 7 .5 %). The adverse reactions were spontaneously relieved within three days after vaccination.
Conclusion: Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 1 1 -1 2 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.
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KEYWORD
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Diphtheria-Tetanus vaccine, Immunization, Efficiency, Safety
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